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Study Design and Baseline Profiles of Participants in the Tianjin Birth Cohort (TJBC) in China

所属课题：	京津冀地区婴幼儿及儿童青少年生长发育队列研究
课题所属机构：	天津市妇幼保健中心
成果类型：	论文
通讯作者：	Puyi Qian,Lingyan Feng,Fang Chen,Gongshu Liu
论文作者：	Shuo Wang Guohong Zhang Jing Wang Zhiqiang Ye Huikun Liu Lingyao Guan Yijuan Qiao Jiayu Chen Tao Zhang Qian Zhao Yu Zhang Bo Wang Ya Gao Puyi Qian Lingyan Feng Fang hen Gongshu Liu
关键词：	design,birth cohort,child,early-onset chronic disease,biobank
摘要：	Background: To investigate the causal link between early-life exposures and long-term health consequences, we established the Tianjin Birth Cohort (TJBC), a large-scale prospective cohort in northern China. Methods: TJBC aims to enroll 10,000 families with follow-ups from pregnancy until children’s six year-old. Pregnant women and their spouses were recruited through a three-tier antenatal healthcare system at early pregnancy, with follow-ups at midpregnancy, late pregnancy, delivery, 42 days after delivery, 6 months after delivery, and each year until 6 years old. Antenatal=neonatal examination, biological samples and questionnaires were collected.Results: From August 2017 to January 2019, a total of 3,924 pregnant women have already been enrolled, and 1,697 women have given birth. We observed the prevalence of gestational diabetes mellitus as 18.1%, anemia as 20.4%, and thyroid hypofunction as 2.0%. In singleton live births, 5.6% were preterm birth (PTB), 3.7% were low birth weight, and 7.3% were macrosomia. Based on current data, we also identified maternal=paternal factors which increased the risk of PTB, including paternal age (OR 1.07; 95% CI, 1.01–1.14 for each year increase), vaginal bleeding during pregnancy (OR 2.82; 95% CI, 1.54–5.17) and maternal early-pregnancy BMI (OR 1.08; 95% CI, 1.01–1.15 for each kg=m2 increase).Conclusion: TJBC has the strength of collecting comprehensive maternal, paternal, and childhood information. With a diverse range of biological samples, we are also engaging with emerging new technologies for multi-omics research. The study would provide new insight into the causal link between macro=micro-environmental exposures of early life and short=long-term health consequences.

发表 2020-10-03

Study Design and Baseline Profiles of Participants in the Tianjin Birth Cohort (TJBC) in China.pdf